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PrimeStore MTM | LHNVD

PrimeStore® MTM

PrimeStore MTM is the only media on the FDA preferred list that inactivates SARS-CoV-2 during the collection and transit stage.

(Data available on request)

PrimeStore® Molecular Transport Medium (MTM) was invented in 2006 in preparation for a Worldwide pandemic which at the time was expected to be H5N1 influenza.  It was designed to rapidly inactivate viruses (including SARS-CoV-2 and Influenza), bacteria (including MTB) and high consequence veterinary pathogens (including ASFv, CSFv, FMDv, HPAI, and NDv) within the sample and stabilize the RNA and DNA to provide safer and more efficient workflow for molecular testing and sequencing. The cold chain is not needed for transportation from collection to the laboratory.  It disrupts/lyses lipid membranes, destroys proteins and enzymes, inactivates nucleases and proteases, inactivates infectious biological pathogens, including gram-positive/negative bacteria and viruses, and preserves/stabilizes ‘naked’ RNA/DNA at elevated temperatures.

PrimeStore® MTM  is compatible with most silica based spin column and magnetic bead extraction kits and systems to include those from Thermo Fisher, Roche Molecular, Qiagen, Thermo Fisher and BioMerieux.  

Tubes currently offered:

  • 2mL cryo tube with 1.0 mL fill

  • 3mL cryo tube with 1.5 mL fill

  • 5mL cryotube with 1.5 mL fill

  • 5mL* wide mouth tube with 1.5 mL fill (new highly durable tube with tight seal cap)

  • 15mL* wide mouth tube with 2.0 mL fill (new highly durable tube with tight seal cap)

 

* Large US based supplier allows production to be scalable into the millions per week beginning week of June 15, 2020

 

LHNVD has other molecular grade transport products if viability of the sample is required, but due to production constraints are not being offered at this time.

*Tested by USDA Foreign Animal Disease Diagnostic Laboratory 

PrimeStore MTM is not compatible with the Hologic Panther System due to an unnecessary disinfecting step involving bleach that is specific to that platform.

PrimeStore MTM for Microbial Inactivation

PrimeStore® MTM is intended for the stabilization, transportation and inactivation of infectious unprocessed nasal washes suspected of containing Influenza A virus RNA. PrimeStore® MTM is also intended for the stabilization, transportation and inactivation of infectious unprocessed sputum samples suspected of containing Mycobacterium tuberculosis DNA from human samples. ​​

PrimeStore® MTM has been demonstrated to completely inactivate viruses, bacteria, and fungi. Multiple studies have demonstrated that PrimeStore® MTM reduces Bacillus spores by three to four logs. Samples suspected of containing spores should be treated as though viable spores remain.

PrimeStore for the Developing World

Sample collection is one of the greatest challenges in the developing world. Whether in a remote village or a densely populated city, collecting a quality sample and transporting it in a safe a timely manner to a laboratory that can effectively test that sample using modern molecular platforms is a current challenge that is greatly alleviated by PrimeStore® MTM.

PrimeStore® MTM has been used by researchers in remote regions of Nepal, India, China, South Africa, Peru, Pakistan, Papua New Guinea, and Ukraine, as well as densely populated cities such as Mumbai, Pretoria, Macau and Singapore. Human, animal, and plant samples shipped in PrimeStore® MTM consistently outperform other sample collection systems leading to more effective and accurate molecular testing.  Even where point of care systems such as the Cepheid GeneXpert MTB/RIF test are deployed, PrimeStore® MTM has demonstrated the ability to improve sensitivity in low copy samples and allow for the same sample to be transported for additional drug susceptibility testing (DST).  

 

Most pandemic diseases originate from the developing world. The ability to screen samples for novel and emerging pathogens using the most modern and accurate molecular tests is essential for early detection and action to prevent large outbreaks.

 

Special pricing is available for the developing world. 

qPCR and NGS

PrimeStore® MTM is compatible with a wide range of spin column and bead based extraction systems providing high quality RNA, DNA, mRNA for molecular analysis.

Animal Surveillance

The USDA Foreign Animal Disease Diagnostics Laboratory, through extensive testing, determined when used as directed, PrimeStore® MTM inactivates African Swine Fever, Classic Swine Fever, and Foot and Mouth Disease and stabilizes nucleic acid for molecular testing.

BioBanking

Every component of the PrimeStore® MTM system is optimized for quick and easy entry into the biobanking process. A sample placed in PrimeStore® MTM is ready for biobanking with no additional steps and no additional supplies.