Vaccines

Longhorn's Vaccine Group, based in Gaithersburg, MD, develops monoclonal antibodies and active vaccines for preventing infectious diseases.

 

Lead Candidates

  

Broadly Reactive/ Universal Influenza

 

Composite Peptide Conjugate Vaccines Induced Broadly Reactive Serum and Monoclonal Antibodies to Influenza

Presented by Clara J. Sei, Director, Microbiology and Immunology Laboratory 

Tuesday, November 13th, 2018 International Society for Influenza and Other Respiratory Virus Diseases

Presented at ECCMID 2019

Paper poster #P0763 (Session: New Therapeutic Approaches in Viral Infections) Sunday 14th at 12:30

Clara J. Sei, Nimisha Rikhi, Richard F. Schuman, Kevin Muema, Aissatou Mbaye, Luke T. Daum, Gerald W Fischer

Broadly reactive monoclonal antibodies to conserved haemagglutinin, neuraminidase, and matrix ectodomain influenza epitopes may provide new therapeutic strategies

 

​​M. tuberculosis

 

Opsonic Monoclonal Antibodies Directed Against MTB Enhance Blood Clearance in a Quantitative qPCR Mouse Model

Clara J. Sei (1*), Luke T. Daum (2), Richard F. Schuman (3), Afia Mesadieu (1), Nimisha Rikhi (1),  Gerald W. Fischer (1)

(1) Longhorn Vaccines and Diagnostics, Gaithersburg, Maryland, USA

(2) Longhorn Vaccines and Diagnostics, San Antonio, Texas, USA

(3) Antibody and Immunoassay Consultants, Rockville, Maryland, USA

Antibody Mediated Killing of Mycobacteria by Macrophage Cells Correlates with In Vivo Blood Clearance of Mycobacterium tuberculosis

Clara J. Sei (1*), Nimisha Rikhi (1), Richard F. Schuman (3), Luke T. Daum (2), Kevin Muema (1), John D. Rodriguez (2), and Gerald W. Fischer (1)

(1) Longhorn Vaccines and Diagnostics, Gaithersburg, Maryland, USA

(2) Longhorn Vaccines and Diagnostics, San Antonio, Texas, USA

(3) Antibody and Immunoassay Consultants, Rockville, Maryland, USA

Presented at ECCMID 2019

Oral #O0935 (Session: Cutting Edge in TB) Monday 15th at 17:12

Bong-Akee Shey, Clara J. Sei, Kudzai Nyazema, Theresa Rossouw, Nontuthuko Maningi, Gerald W Fischer, Bernard Fourie

A novel monoclonal antibody enhances phagocytosis and killing of Mycobacterium tuberculosis in macrophage cells